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Dorsch Dorsch W. Klinische Anwendung von Extrakten aus Echinacea purpurea oder Echinacea pallida. Haustein Haustein KO. Immunotherapeutics [Immuntherapeutika]. In: Schwabe U, Paffrath D editor s. Arzneiverordnungsreport ' Jadad Assessing the quality of reports of randomized trials: is blinding necessary?

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Linde a. Linde b. Schulz Empirical evidence of bias. Are herbal immunomodulators effective and safe? Characteristics of studies. Characteristics of included studies [ordered by study ID] scolaris. Dorn Forth Freyer Helbig Henneicke Hoheisel Kleinschmidt Melchart Reitz Scaglione Schmidt Vorberg Characteristics of excluded studies [ordered by study ID] scolaris. Data and analyses. Open in table viewer Comparison 1.

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Echinacea vs. Open in figure viewer Descargar como PowerPoint Analysis 1. Open in table viewer Comparison 2. Open in figure viewer Descargar como PowerPoint Analysis 2. Open in table viewer Comparison 3. Open in figure viewer Descargar como PowerPoint Analysis 3. Figuras y tablas -. Comparison 1. Comparison 2. Comparison 3.

Descargar Incluir resumen. Figuras Tablas.

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Ocultar vista en miniatura acercar alejar. Aceptar Cancelar. Visit Cochrane. Acceso institucional. Cochrane Login Usuario. S: one general practice, Germany. Risk of bias. Support for judgement.

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Allocation concealment selection bias. T: Echinacea pallida root extract 90 drops mg daily for 8 to 10 days C: placebo. S: industrial plant, Germany. Number of patients who experienced a running nose. Number of children with infections, days with fever. Symptoms assessed after seven and 14 days , immunological analyses and recurrence. B: single S:? N: 32?

Incidence of infections, symptom monitoring in case of infections. T: pressed juice of Echinacea purpurea herb, 2x4 ml daily for 8 weeks C: placebo. Nine symptoms assessed after two to three and eight to ten days. Baetgen Not randomized Not common cold pertussis. Not randomized Not common cold acute bronchitis.

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Bendel Not common cold angina lacunaris. The computations were performed on a network of processors located at Rice University and Princeton University see the Princeton external link. The total computation time was equivalent to In May , the travelling salesman problem of visiting all 24, towns in Sweden was solved: a tour of length approximately 72, kilometers was found and it was proven that no shorter tour exists.

In March , the travelling salesman problem of visiting all 33, points in a circuit board was solved using Concorde TSP Solver : a tour of length 66,, units was found and it was proven that no shorter tour exists. The computation took approximately Various heuristics and approximation algorithms , which quickly yield good solutions have been devised. The nearest neighbour NN algorithm or so-called greedy algorithm lets the salesman choose the nearest unvisited city as his next move.

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This algorithm quickly yields an effectively short route. However, there exist many specially arranged city distributions which make the NN algorithm give the worst route Gutin, Yeo, and Zverovich, Rosenkrantz et al. MTS has been shown to empirically outperform all existing tour construction heuristics. MTS performs two sequential matchings, where the second matching is executed after deleting all the edges of the first matching, to yield a set of cycles. The cycles are then stitched to produce the final tour.

TSP is a touchstone for many general heuristics devised for combinatorial optimization such as genetic algorithms , simulated annealing, Tabu search, ant colony optimization, and the cross entropy method. While David Goldberg wrote about this method in terms of DNA [20] , it is repeated here in terms of a travelling salesman.

This method shortens the path by opening loops at random. After all the loops are opened, one final loop remains that defines a perimeter. While a perimeter is not always the optimal path, it is usually very close. In a special case when all towns are equidistantly placed along a circle, the perimeter is the optimal solution.

Suppose a salesman has a deck of 60 cards, each with the location of a different town. He wants to find the optimal path by arranging the cards, calculating the length, and comparing results over and over. This is more than the estimated number of atoms in the observable universe! With this method, he likely won't find the optimal path or even get close before dying of old age. Using inversion instead, the salesman starts with the shuffled cards laid out in front of him.

First, he calculates the path length. Then he randomly picks four contiguous cards and inverts their order i. After recalculating the path length, he keeps the new order if it is shorter as in the figure below with 6 towns note: the hometown, point 1, is not counted. For 60 towns, a loop is randomly opened more than once in every 60 2 attempts.

If the salesman has a friend with an identical card deck, then they can double their chances of opening a loop. They both lay out the cards in the same order, then randomly select different sets of four cards to invert. Naturally, more friends working in parallel will continue to improve the odds. The figure below shows a randomly generated path connecting 60 points. Each iteration has parallel inversion operations i. See figure below. Out of 4. ACS sends out a large number of virtual ant agents to explore many possible routes on the map.

Each ant probabilistically chooses the next city to visit based on a heuristic combining the distance to the city and the amount of virtual pheromone deposited on the edge to the city. The ants explore, depositing pheromone on each edge that they cross, until they have all completed a tour.